Publications

At the University of Kentucky

  • Heidary, D., Fox, A., Richards, C., Glazer, E.C., “A high-throughput screening assay using a photoconvertable protein for identifying inhibitors of transcription, translation, or proteasomal degradation”, SLAS Discovery, 2016, in press.
    http://journals.sagepub.com/doi/full/10.1177/2472555216684333
  • Wachter, E., Moya, D., Glazer, E.C., “Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds” ACS Combinatorial Science, 2016, Advance Article.
  • Wachter, E., Zamora, A., Heidary, D.K., Ruiz, J., Glazer, E.C., “Geometry Matters: Inverse Cytotoxic Relationship for cis/trans-Ru(II) Polypyridyl Complexes from cis/trans-[PtCl2(NH3)2]” ChemComm, 2016, 52, 1021-24; back cover.

    Cover art by Leona Nease, an undergraduate student in the lab.
  • Geronimo, I., Denning, C.A., Rogers, W.E., Othman, T., Huxford, T., Heidary, D.K., Glazer, E.C., Payne, C.M., “Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants”, Biochemistry, 2016, 55, 3594-606.
  • Wachter, E, Glazer, E.C., Parkin, S., Brock, C.P., “An Exceptional 5:4 Enantiomeric Structure” Acta Cryst. B 2016, B72, 223-31.
  • Dickerson, M., Howerton, B.S., Bae, Y., Glazer, E.C., “Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer” J. Materials Chem. B. 2016, 4, 394-408.
    http://pubs.rsc.org/en/content/articlepdf/2016/tb/c5tb01613d
  • Wachter, E., Moya, D., Parkin, S., Glazer, E.C., “Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures” Chem. Eur. J. , 22, 550-9.
    http://onlinelibrary.wiley.com/doi/10.1002/chem.201503203/full
  • Heidary, D.K., Howerton, B.S., Glazer, E.C., “Coordination of quinolines to ruthenium bis-dimethyl-phenanthroline improves potency for potential antineoplastic agents”, J. Med. Chem. 2014, 57, 8936-8946.
    http://pubs.acs.org/doi/abs/10.1021/jm501043s
  • Hidayatullah, A.N., Wachter, E., Heidary, D.K., Parkin, S., Glazer, E.C., “Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents”, Inorg. Chem. 2014, 53, 10030-10032.
    http://pubs.acs.org/doi/abs/10.1021/ic5017164
  • Dickerson, M., Sun, Y., Glazer, E.C., “Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: old complexes, surprising new tricks”, Inorg. Chem. 2014, 53, 10370-10377.
    http://pubs.acs.org/doi/abs/10.1021/ic5013796
  • Wachter, E., Glazer, E.C., “Mechanistic study on the photochemical “light-switch” behavior of [Ru(bpy)2dmdppz]2+”, to be included in the special issue “Current Topics in Photochemistry” in J. Phys. Chem. A 2014 (DOI: 10.1021/jp504249a).
    http://pubs.acs.org/doi/abs/10.1021/jp504249a
  • Heidary, D. K., Glazer, E. C., “A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay", ChemBioChem 2014, 15, 507-511.
    http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300681/abstract
  • Wachter, E., Howerton, B. S., Hall, E. C., Parkin, S. Glazer, E. C., “A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA”, ChemComm 2014, 50, 311-313.
    http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c3cc47269h#!divAbs...
  • Glazer, E. C. “Light-activated metal complexes that covalently modify DNA”, invited review, Israel Journal of Chemistry special issue on “Contemporary Topics in Nucleic Acids”; 2013, 53, 391-400.
  • Wachter, E., Heidary, D. K., Howerton, B. S., Glazer, E. C., “Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window”, ChemComm 2012, 48, 9649-9651.
    http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c2cc33359g#!divAbs...
  • Howerton, B. S., Heidary, D. K., Glazer, E. C. “Strained ruthenium complexes are potent light-activated anticancer agents”, J. Am. Chem. Soc. 2012, 134, 8324-8327.
    http://pubs.acs.org/doi/abs/10.1021/ja3009677

Highlighted in C&E News

Prior to the University of Kentucky

  • Lee, Y. T.*, Glazer, E. C.*, Wilson, R. F., Stout, C. D., and Goodin, D. B. “Three clusters of conformational states in P450cam reveals a multi-step pathway for opening of the substrate access channel”, Biochemistry 2011, 50, 693-703.
  • Glazer, E. C., Nguyen, Y. H., Goodin, D. B., Gray, H.B. “Probing inducible nitric oxide synthase with a pterin-Ru(II) sensitizer wire”, Angew. Chem. 2008, 47, 898-901.
  • Glazer, E. C., Magde, D., Tor, Y. “Ru(II) complexes that break the rules: structural features regulating dual emission”, J. Am. Chem. Soc. 2007, 129, 8544-8551.
  • Contakes, S. M., Nguyen, Y. H., Gray, H. B., Glazer, E. C., Hays, A. M., Goodin, D. B.  “Conjugates of heme-thiolate enzymes with photoactive metal-diimine wires”, Structure and Bonding, 2007, 123, 177-203.
  • Jouvenot, D., Glazer, E. C., Tor, Y. “Photodimerizable ditopic ligand”, Org. Lett. 2006, 8, 1987-1990.
  • Udit, A. K., Belliston-Bittner, W., Glazer, E. C., Nguyen, Y. H., Gillan, J. M., Hill, M. G., Marletta, M. A., Goodin, D. B., Gray, H. B. “Redox couples of inducible nitric oxide synthase”, J. Am. Chem. Soc. 2005, 127, 11212-3.
  • Glazer, E. C., Belyea, B., Tor, Y. “A simple synthesis of isotopically pure 2,2'-bipyridyl-d8”, Inorg. Chem. Comm. 2005, 8, 517-519.
  • Glazer, E. C., Magde, D., Tor, Y.  “Dual emission from a family of conjugated dinuclear RuII complexes”, J. Am. Chem. Soc. 2005, 127, 4190-4192.
  • Aldrich-Wright, J., Brodie, C., Glazer, E. C., Luedtke, N. W., Elson-Schwab, L., Tor, Y.  “Symmetrical bisintercalating complexes based on [Ru(dpq)2(phen)]2+ with high DNA affinity”,  Chem. Comm. 2004, 8, 1018-1019.
  • Glazer, E. C., Tor, Y. “Ru(II) complexes of "large-surface" ligands”, Angew. Chem. 2002, 41, 4022-4026.
  • Luedtke, N. W., Hwang, J. S., Glazer, E. C., Gut, D., Kol, M., Tor, Y. “Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA”, ChemBioChem 2002, 3, 766-771.
  • Glazer, E. C., Tor, Y.  “Chiral metal-containing polymers”, Polymer Preprints 1999, 40, 513-514.
  • Diaz-Garcia, M. A., Wright, D., Casperson, J. D., Smith, B., Glazer, E., Moerner, W. E., Sukhomlinova, L. I., Twieg, R. J.  “Photorefractive properties of poly(N-vinyl carbazole)-based composites for high-speed applications”, Chemistry of Materials 1999, 11, 1784-1791.