Publications

At the University of Kentucky:

Heidary, D., Fox, A., Richards, C., Glazer, E.C., “A high-throughput screening assay using a photoconvertable protein for identifying inhibitors of transcription, translation, or proteasomal degradation”, SLAS Discovery, 2016, in press.

http://journals.sagepub.com/doi/full/10.1177/2472555216684333

Wachter, E., Moya, D., Glazer, E.C., “Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds” ACS Combinatorial Science, 2016, Advance Article.

Wachter, E., Zamora, A., Heidary, D.K., Ruiz, J., Glazer, E.C., “Geometry Matters: Inverse Cytotoxic Relationship for cis/trans-Ru(II) Polypyridyl Complexes from cis/trans-[PtCl2(NH3)2]” ChemComm, 2016, 52, 1021-24; back cover.

Cover art by Leona Nease, an undergraduate student in the lab.

Geronimo, I., Denning, C.A., Rogers, W.E., Othman, T., Huxford, T., Heidary, D.K., Glazer, E.C., Payne, C.M., “Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants”, Biochemistry, 2016, 55, 3594-606.

Wachter, E, Glazer, E.C., Parkin, S., Brock, C.P., “An Exceptional 5:4 Enantiomeric Structure” Acta Cryst. B 2016, B72, 223-31.

Dickerson, M., Howerton, B.S., Bae, Y., Glazer, E.C., “Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer” J. Materials Chem. B. 2016, 4, 394-408.

 

http://pubs.rsc.org/en/content/articlepdf/2016/tb/c5tb01613d

 

 

 

Wachter, E., Moya, D., Parkin, S., Glazer, E.C., “Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures” Chem. Eur. J. , 22, 550-9.

http://onlinelibrary.wiley.com/doi/10.1002/chem.201503203/full

Heidary, D.K., Howerton, B.S., Glazer, E.C., “Coordination of quinolines to ruthenium bis-dimethyl-phenanthroline improves potency for potential antineoplastic agents”, J. Med. Chem. 2014, 57, 8936-8946.

 

 

http://pubs.acs.org/doi/abs/10.1021/jm501043s

 

 

 

 

Hidayatullah, A.N., Wachter, E., Heidary, D.K., Parkin, S., Glazer, E.C., “Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents”, Inorg. Chem. 2014, 53, 10030-10032.

 

 

 

http://pubs.acs.org/doi/abs/10.1021/ic5017164

 

 

 

Dickerson, M., Sun, Y., Glazer, E.C., “Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: old complexes, surprising new tricks”, Inorg. Chem. 2014, 53, 10370-10377.

 

 

http://pubs.acs.org/doi/abs/10.1021/ic5013796

 

 

 

Wachter, E., Glazer, E.C., “Mechanistic study on the photochemical “light-switch” behavior of [Ru(bpy)2dmdppz]2+”, to be included in the special issue “Current Topics in Photochemistry” in J. Phys. Chem. A 2014 (DOI: 10.1021/jp504249a).

http://pubs.acs.org/doi/abs/10.1021/jp504249a

Heidary, D. K., Glazer, E. C., “A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay", ChemBioChem 2014, 15, 507-511. 

 

 

 

http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300681/abstract

 

 

 

 

Wachter, E., Howerton, B. S., Hall, E. C., Parkin, S. Glazer, E. C., “A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA”, ChemComm 2014, 50, 311-313.

 

 

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c3cc47269h#!divAbs...

 

 

 

 

Glazer, E. C. “Light-activated metal complexes that covalently modify DNA”, invited review, Israel Journal of Chemistry special issue on “Contemporary Topics in Nucleic Acids”; 2013, 53, 391-400.

Wachter, E., Heidary, D. K., Howerton, B. S., Glazer, E. C., “Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window”, ChemComm 2012, 48, 9649-9651.

 

 

 

http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c2cc33359g#!divAbs...

 

 

 

 

Howerton, B. S., Heidary, D. K., Glazer, E. C. “Strained ruthenium complexes are potent light-activated anticancer agents”, J. Am. Chem. Soc. 2012, 134, 8324-8327.

http://pubs.acs.org/doi/abs/10.1021/ja3009677

Highlighted in C&E News:

http://cen.acs.org/articles/90/web/2012/05/Turning-Ruthenium-Kill-Cancer...

http://cen.acs.org/signin.html?resource=/content/cen/articles/90/i21/Rut...

 

Prior to the University of Kentucky:

Lee, Y. T.*, Glazer, E. C.*, Wilson, R. F., Stout, C. D., and Goodin, D. B. “Three clusters of conformational states in P450cam reveals a multi-step pathway for opening of the substrate access channel”, Biochemistry 2011, 50, 693-703.

Glazer, E. C., Nguyen, Y. H., Goodin, D. B., Gray, H.B. “Probing inducible nitric oxide synthase with a pterin-Ru(II) sensitizer wire”, Angew. Chem. 2008, 47, 898-901.

Glazer, E. C., Magde, D., Tor, Y. “Ru(II) complexes that break the rules: structural features regulating dual emission”, J. Am. Chem. Soc. 2007, 129, 8544-8551.

Contakes, S. M., Nguyen, Y. H., Gray, H. B., Glazer, E. C., Hays, A. M., Goodin, D. B.  “Conjugates of heme-thiolate enzymes with photoactive metal-diimine wires”, Structure and Bonding, 2007, 123, 177-203.

Jouvenot, D., Glazer, E. C., Tor, Y. “Photodimerizable ditopic ligand”, Org. Lett. 2006, 8, 1987-1990.

Udit, A. K., Belliston-Bittner, W., Glazer, E. C., Nguyen, Y. H., Gillan, J. M., Hill, M. G., Marletta, M. A., Goodin, D. B., Gray, H. B. “Redox couples of inducible nitric oxide synthase”, J. Am. Chem. Soc. 2005, 127, 11212-3.

Glazer, E. C., Belyea, B., Tor, Y. “A simple synthesis of isotopically pure 2,2'-bipyridyl-d8”, Inorg. Chem. Comm. 2005, 8, 517-519.

Glazer, E. C., Magde, D., Tor, Y.  “Dual emission from a family of conjugated dinuclear RuII complexes”, J. Am. Chem. Soc. 2005, 127, 4190-4192.

Aldrich-Wright, J., Brodie, C., Glazer, E. C., Luedtke, N. W., Elson-Schwab, L., Tor, Y.  “Symmetrical bisintercalating complexes based on [Ru(dpq)2(phen)]2+ with high DNA affinity”,  Chem. Comm. 2004, 8, 1018-1019.

Glazer, E. C., Tor, Y. “Ru(II) complexes of "large-surface" ligands”, Angew. Chem. 2002, 41, 4022-4026.

Luedtke, N. W., Hwang, J. S., Glazer, E. C., Gut, D., Kol, M., Tor, Y. “Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA”, ChemBioChem 2002, 3, 766-771.

Glazer, E. C., Tor, Y.  “Chiral metal-containing polymers”, Polymer Preprints 1999, 40, 513-514.

Diaz-Garcia, M. A., Wright, D., Casperson, J. D., Smith, B., Glazer, E., Moerner, W. E., Sukhomlinova, L. I., Twieg, R. J.  “Photorefractive properties of poly(N-vinyl carbazole)-based composites for high-speed applications”, Chemistry of Materials 1999, 11, 1784-1791. 

 

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